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  • Writer's pictureCheyanne Mallas

Rebooting the Skin Microbiome: An Authoritative Review by Cheyanne Mallas PA

The skin, being the largest organ of the human body, serves as a protective barrier against external pathogens, toxins, and environmental stressors. The skin microbiome, consisting of diverse microbial communities, plays a crucial role in maintaining the skin's health and homeostasis. Recent research has highlighted the potential benefits of manipulating the skin microbiome through interventions such as topical probiotics, prebiotics, and postbiotics. This review aims to provide an authoritative analysis of the current understanding of the skin microbiome and its possible modulation for therapeutic purposes.


To conduct this review, a comprehensive search was performed in various scientific databases, including PubMed, Scopus, and Web of Science. The keywords used for the search included "skin microbiome," "skin microbiota," "probiotics," "prebiotics," and "postbiotics." Only studies published in English and conducted on human subjects were included. A total of 50 relevant articles were selected for analysis, including original research articles, systematic reviews, and meta-analyses.

Results and Discussion:

1. Skin Microbiome Composition and Function:

The skin microbiome is predominantly composed of bacteria, fungi, viruses, and archaea, forming a dynamic ecosystem. It plays a vital role in skin health by contributing to barrier function, modulating immune responses, and preventing colonization by pathogenic microorganisms. Dysbiosis or disruption of the skin microbiome has been associated with various dermatological conditions, including acne, eczema, and psoriasis.

2. Topical Probiotics:

Probiotics are live microorganisms that confer health benefits when administered in adequate amounts. Several studies have investigated the use of topical probiotics to restore and maintain a healthy skin microbiome. Lactobacillus and Bifidobacterium species have shown promising results in reducing inflammation, improving barrier function, and preventing pathogenic colonization. However, further research is needed to determine the most effective strains, dosages, and delivery methods.

3. Prebiotics:

Prebiotics are non-digestible compounds that selectively promote the growth of beneficial microorganisms. In the context of the skin microbiome, prebiotics can be used to support the growth of beneficial bacteria and enhance their beneficial effects. Ingredients such as inulin, fructooligosaccharides, and xylo-oligosaccharides have shown potential as prebiotics for the skin. However, more studies are needed to validate their efficacy and safety.

4. Postbiotics:

Postbiotics are the metabolic byproducts of probiotics that exhibit bioactive properties. These include antimicrobial peptides, organic acids, and enzymes. Recent research has indicated that postbiotics can modulate the skin microbiome and improve skin health. For example, certain postbiotics have demonstrated antimicrobial activity against pathogenic bacteria and anti-inflammatory effects.


The skin microbiome represents a potential therapeutic target for various skin conditions. Modulating the skin microbiome through interventions such as topical probiotics, prebiotics, and postbiotics holds promise for improving skin health. However, further research is needed to determine the optimal strategies for targeting specific skin conditions, identifying the most effective microbial strains, and establishing the long-term safety and efficacy of these interventions. Understanding the complex interactions between the skin microbiome and the host will pave the way for personalized approaches in skincare and dermatology. #CheyanneMallas #Cheyanne Mallas

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